Departmental Publications 2022

Assessing acute myeloid leukemia susceptibility in rearrangement-driven patients by DNA breakage at topoisomerase II and CCCTC-binding factor/cohesin binding sites. Atkin ND, Raimer HM, Wang Z, Zang C, Wang YH. Genes Chromosomes Cancer. 2021 Dec;60(12):808-821. doi: 10.1002/gcc.22993. Epub 2021 Aug 26. PMID: 34405474

Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models. Dutta A, Nath D, Yang Y, Le BT, Rahman MF, Faughnan P, Wang Z, Stuver M, He R, Tan W, Hutchison RE, Foulks JM, Warner SL, Zang C, Mohi G. Leukemia. 2022 Mar;36(3):746-759. doi: 10.1038/s41375-021-01464-2. Epub 2021 Nov 5. PMID: 34741118

Correlation of ATP7B gene mutations with clinical phenotype and radiological features in Indian Wilson disease patients. Chaudhuri J, Biswas S, Gangopadhyay G, Biswas T, Datta J, Biswas A, Pandit A, Datta AK, Mukherjee A, Dutta AK, Bhattacharya P, Hazra A. Acta Neurol Belg. 2022 Feb;122(1):181-190. doi: 10.1007/s13760-021-01816-w. Epub 2021 Oct 13. PMID: 34643937

Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.  Wang F, Cvirkaite-Krupovic V, Vos M, Beltran LC, Kreutzberger MAB, Winter JM, Su Z, Liu J, Schouten S, Krupovic M, Egelman EH. Cell. 2022 Mar 17:S0092-8674(22)00199-4. doi: 10.1016/j.cell.2022.02.019. Online ahead of print. PMID: 35325592

Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments. Kreutzberger MAB, Sobe RC, Sauder AB, Chatterjee S, Peña A, Wang F, Giron JA, Kiessling V, Costa TRD, Conticello VP, Frankel G, Kendall MM, Scharf BE, Egelman EH. Nat Commun. 2022 Mar 17;13(1):1422. doi: 10.1038/s41467-022-29069-y.PMID: 35301306Free PMC article.

Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models. Dutta A, Nath D, Yang Y, Le BT, Rahman MF, Faughnan P, Wang Z, Stuver M, He R, Tan W, Hutchison RE, Foulks JM, Warner SL, Zang C, Mohi G. Leukemia. 2022 Mar;36(3):746-759. doi: 10.1038/s41375-021-01464-2. Epub 2021 Nov 5. PMID: 34741118

CDK6 Is a Therapeutic Target in Myelofibrosis.  Dutta A, Nath D, Yang Y, Le BT, Mohi G. Cancer Res. 2021 Aug 15;81(16):4332-4345. doi: 10.1158/0008-5472.CAN-21-0590. Epub 2021 Jun 18. PMID: 34145036.

PEPPRO: quality control and processing of nascent RNA profiling data.  Smith JP, Dutta AB, Sathyan KM, Guertin MJ, Sheffield NC. Genome Biol. 2021 May 15;22(1):155. doi: 10.1186/s13059-021-02349-4. PMID: 33992117

Atomic structure of Lanreotide nanotubes revealed by cryo-EM.  Pieri L, Wang F, Arteni AA, Vos M, Winter JM, Le Du MH, Artzner F, Gobeaux F, Legrand P, Boulard Y, Bressanelli S, Egelman EH, Paternostre M. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2120346119. doi: 10.1073/pnas.2120346119. PMID: 35042822

A Genomic-Pathologic Annotated Risk Model to Predict Recurrence in Early-Stage Lung Adenocarcinoma.  Jones GD, Brandt WS, Shen R, Sanchez-Vega F, Tan KS, Martin A, Zhou J, Berger M, Solit DB, Schultz N, Rizvi H, Liu Y, Adamski A, Chaft JE, Riely GJ, Rocco G, Bott MJ, Molena D, Ladanyi M, Travis WD, Rekhtman N, Park BJ, Adusumilli PS, Lyden D, Imielinski M, Mayo MW, Li BT, Jones DR. JAMA Surg. 2021 Feb 1;156(2):e205601. doi: 10.1001/jamasurg.2020.5601. Epub 2021 Feb 10.

HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes.  Kiran S, Wilson B, Saha S, Graff JA, Dutta A. Cancers (Basel). 2021 Dec 22;14(1):30. doi: 10.3390/cancers14010030. PMID: 35008200

The tumor-suppressive long noncoding RNA DRAIC inhibits protein translation and induces autophagy by activating AMPK.  Saha S, Zhang Y, Wilson B, Abounader R, Dutta A. J Cell Sci. 2021 Dec 15;134(24):jcs259306. doi: 10.1242/jcs.259306. Epub 2021 Dec 20. PMID: 34746949

Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A.  Lee KY, Dutta A. Cell Rep. 2021 Jan 26;34(4):108680. doi: 10.1016/j.celrep.2020.108680. PMID: 33503415

Reconstitution of the DTX3L-PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly.  Ashok Y, Vela-Rodríguez C, Yang C, Alanen HI, Liu F, Paschal BM, Lehtiö L.Biochem J. 2022 Feb 11;479(3):289-304. doi: 10.1042/BCJ20210722. PMID: 35037691

Inhibition of DYRK1a Enhances Cardiomyocyte Cycling After Myocardial Infarction. Young A, Bradley LA, Farrar E, Bilcheck HO, Tkachenko S, Saucerman JJ, Bekiranov S, Wolf MJ. Circ Res. 2022 Apr 29;130(9):1345-1361. doi: 10.1161/CIRCRESAHA.121.320005. Epub 2022 Apr 4. PMID: 35369706

TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R, Dutta A. Nat Commun. 2022 Apr 20;13(1):2165. doi: 10.1038/s41467-022-29790-8. PMID: 35444240

Integrated bioinformatic pipeline using whole-exome and RNAseq data to identify germline variants correlated with cancer. Sahu D, Chatrath A, Ratan A, Dutta A. STAR Protoc. 2022 Apr 4;3(2):101273. doi: 10.1016/j.xpro.2022.101273. eCollection 2022 Jun 17. PMID: 35403010

ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines. Kumar P, Kiran S, Saha S, Su Z, Paulsen T, Chatrath A, Shibata Y, Shibata E, Dutta A. Sci Adv. 2020 May 15;6(20):eaba2489. doi: 10.1126/sciadv.aba2489. eCollection 2020 May. PMID: 32440553