Departmental Publications 2021

The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation.  Tseng YJ, Sandwith SN, Green KM, Chambers AE, Krans A, Raimer HM, Sharlow ME, Reisinger MA, Richardson AE, Routh ED, Smaldino MA, Wang YH, Vaughn JP, Todd PK, Smaldino PJ. J Biol Chem. 2021 Aug;297(2):100914. doi: 10.1016/j.jbc.2021.100914. Epub 2021 Jun 24.PMID: 34174288

MicroDNA levels are dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA damage.  Paulsen T, Malapati P, Shibata Y, Wilson B, Eki R, Benamar M, Abbas T, Dutta A. Nucleic Acids Res. 2021 Nov 18;49(20):11787-11799. doi: 10.1093/nar/gkab984. PMID: 34718766

Genomic analyses of the metastasis-derived prostate cancer cell lines LNCaP, VCaP, and PC3-AR. Sienkiewicz K, Yang C, Paschal BM, Ratan A. Prostate. 2021 Dec 24:e24290. doi: 10.1002/pros.24290. Online ahead of print. PMID: 34951700

PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus. Kamata T, Yang CS, Paschal BM. Biochem J. 2021 Aug 13;478(15):2999-3014. doi: 10.1042/BCJ20210378. PMID: 34264286

A tumor suppressive long noncoding RNA, DRAIC, inhibits protein translation and induces autophagy by activating AMPK.  Saha S, Zhang Y, Wilson B, Abounader R, Dutta A. J Cell Sci. 2021 Nov 8:jcs.259306. doi: 10.1242/jcs.259306. PMID: 34746949

Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models.  Dutta A, Nath D, Yang Y, Le BT, Rahman MF, Faughnan P, Wang Z, Stuver M, He R, Tan W, Hutchison RE, Foulks JM, Warner SL, Zang C, Mohi G. Leukemia. 2021 Nov 5. doi: 10.1038/s41375-021-01464-2. PMID: 34741118

IGF1R and Src inhibition induce synergistic cytotoxicity in HNSCC through inhibition of FAK.  Lehman CE, Spencer A, Hall S, Shaw JJP, Wulfkuhle J, Petricoin EF, Bekiranov S, Jameson MJ, Gioeli D. Sci Rep. 2021 May 24;11(1):10826. doi: 10.1038/s41598-021-90289-1. PMID: 34031486

Epigenetic condensates regulate chromatin activity and tumorigenesis.  Shi B, Li W, Jiang H. Mol Cell Oncol. 2021 Nov 9;8(5):1997040. doi: 10.1080/23723556.2021.1997040. eCollection 2021. PMID: 34859151

Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models.  Dutta A, Nath D, Yang Y, Le BT, Rahman MF, Faughnan P, Wang Z, Stuver M, He R, Tan W, Hutchison RE, Foulks JM, Warner SL, Zang C, Mohi G. Leukemia. 2021 Nov 5. doi: 10.1038/s41375-021-01464-2. PMID: 34741118

A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors.  Shivange G, Mondal T, Lyerly E, Bhatnagar S, Landen CN, Reddy S, Kim J, Doan B, Riddle P, Tushir-Singh J. Cell Rep. 2021 Nov 2;37(5):109953. doi: 10.1016/j.celrep.2021.109953.PMID: 34731630
Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies.  Mondal T, Shivange GN, Tihagam RG, Lyerly E, Battista M, Talwar D, Mosavian R, Urbanek K, Rashid NS, Harrell JC, Bos PD, Stelow EB, Stack MS, Bhatnagar S, Tushir-Singh J. EMBO Mol Med. 2021 Mar 5;13(3):e12716. doi: 10.15252/emmm.202012716. Epub 2021 Feb 15. PMID: 33587338

Deterministic chaos in the self-assembly of β sheet nanotubes from an amphipathic oligopeptide.  Wang F, Gnewou O, Wang S, Osinski T, Zuo X, Egelman EH, Conticello VP. Matter. 2021 Oct 6;4(10):3217-3231. doi: 10.1016/j.matt.2021.06.037. Epub 2021 Jul 27. PMID: 34632372

Cryoelectron-Microscopic Structure of the pKpQIL Conjugative Pili from Carbapenem-Resistant Klebsiella pneumoniae.  Zheng W, Pena A, Low WW, Wong JLC, Frankel G, Egelman EH. Structure. 2020 Dec 1;28(12):1321-1328.e2. doi: 10.1016/j.str.2020.08.010. Epub 2020 Sep 10. PMID: 32916103

MicroDNA levels are dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA damage.  Paulsen T, Malapati P, Shibata Y, Wilson B, Eki R, Benamar M, Abbas T, Dutta A. Nucleic Acids Res. 2021 Oct 30:gkab984. doi: 10.1093/nar/gkab984. PMID: 34718766

Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling.  Kamata T, Yang CS, Melhuish TA, Frierson HF Jr, Wotton D, Paschal BM. Cells. 2021 Feb 9;10(2):363. doi: 10.3390/cells10020363. PMID: 33572475

Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia.  Rapaport F, Neelamraju Y, Baslan T, Hassane D, Gruszczynska A, Robert de Massy M, Farnoud N, Haddox S, Lee T, Medina-Martinez J, Sheridan C, Thurmond A, Becker M, Bekiranov S, Carroll M, Moses Murdock H, Valk PJM, Bullinger L, D’Andrea R, Lowe SW, Neuberg D, Levine RL, Melnick A, Garrett-Bakelman FE. Leukemia. 2021 Sep;35(9):2688-2692. doi: 10.1038/s41375-021-01153-0. Epub 2021 Feb 12. PMID: 33580203

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.  Alencar GF, Owsiany KM, Karnewar S, Sukhavasi K, Mocci G, Nguyen AT, Williams CM, Shamsuzzaman S, Mokry M, Henderson CA, Haskins R, Baylis RA, Finn AV, McNamara CA, Zunder ER, Venkata V, Pasterkamp G, Björkegren J, Bekiranov S, Owens GK. Circulation. 2020 Nov 24;142(21):2045-2059. doi: 10.1161/CIRCULATIONAHA.120.046672. Epub 2020 Jul 17. PMID: 32674599

Associations of immune cell homing gene signatures and infiltrates of lymphocyte subsets in human melanomas: discordance with CD163+ myeloid cell infiltrates.  Kwak M, Erdag G, Leick KM, Bekiranov S, Engelhard VH, Slingluff CL. J Transl Med. 2021 Aug 28;19(1):371. doi: 10.1186/s12967-021-03044-5. PMID: 34454518

Quantum computing at the frontiers of biological sciences.  Emani PS, Warrell J, Anticevic A, Bekiranov S, Gandal M, McConnell MJ, Sapiro G, Aspuru-Guzik A, Baker JT, Bastiani M, Murray JD, Sotiropoulos SN, Taylor J, Senthil G, Lehner T, Gerstein MB, Harrow AW. PMID: 33398186

Histone H3 lysine 27 acetylation profile undergoes two global shifts in undernourished children and suggests altered one-carbon metabolism.  Kupkova K, Shetty SJ, Haque R, Petri WA Jr, Auble DT. Clin Epigenetics. 2021 Sep 26;13(1):182. doi: 10.1186/s13148-021-01173-8. PMID: 34565452

Structure and assembly of archaeal viruses.  Baquero DP, Liu Y, Wang F, Egelman EH, Prangishvili D, Krupovic M. Adv Virus Res. 2020;108:127-164. doi: 10.1016/bs.aivir.2020.09.004. Epub 2020 Oct 5. PMID: 33837715 Review.

A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance.  Lee HM, Kuijer MB, Ruiz Blanes N, Clark EP, Aita M, Galiano Arjona L, Kokot A, Sciaky N, Simon JM, Bhatnagar S, Philpot BD, Cerase A. J Neurodev Disord. 2020 Nov 10;12(1):29. doi: 10.1186/s11689-020-09332-3. PMID: 33172406

Associations of immune cell homing gene signatures and infiltrates of lymphocyte subsets in human melanomas: discordance with CD163+ myeloid cell infiltrates.  Kwak M, Erdag G, Leick KM, Bekiranov S, Engelhard VH, Slingluff CL. J Transl Med. 2021 Aug 28;19(1):371. doi: 10.1186/s12967-021-03044-5. PMID: 34454518

Special Issue: The Role of Complement in Cancer Immunotherapy.  Taylor RP. Antibodies (Basel). 2021 Jul 23;10(3):29. doi: 10.3390/antib10030029. PMID: 34449550

Risk-adapted, ofatumumab-based chemoimmunotherapy and consolidation in treatment-naïve chronic lymphocytic leukemia: a phase 2 study.  Desai S, Mo C, Gaglione EM, Yuan CM, Stetler-Stevenson M, Tian X, Maric I, Wake L, Farooqui MZ, Drinkwater DC, Soto S, Valdez J, Hughes TE, Nierman P, Lotter J, Marti GE, Pleyer C, Sun C, Superata J, Nichols C, Herman SEM, Lindorfer MA, Taylor RP, Wiestner A, Ahn IE. Leuk Lymphoma. 2021 Aug;62(8):1816-1827. doi: 10.1080/10428194.2021.1888379. Epub 2021 Mar 2. PMID: 33653216Clinical Trial.

U2af1 is required for survival and function of hematopoietic stem/progenitor cells.  Dutta A, Yang Y, Le BT, Zhang Y, Abdel-Wahab O, Zang C, Mohi G. Leukemia. 2021 Aug;35(8):2382-2398. doi: 10.1038/s41375-020-01116-x. Epub 2021 Jan 7. PMID: 33414485

Germline Variants That Affect Tumor Progression.  Chatrath A, Ratan A, Dutta A. Trends Genet. 2021 May;37(5):433-443. doi: 10.1016/j.tig.2020.10.005. Epub 2020 Nov 14. PMID: 33203571

Assessing acute myeloid leukemia susceptibility in rearrangement-driven patients by DNA breakage at topoisomerase II and CCCTC-binding factor/cohesin binding sites.  Atkin ND, Raimer HM, Wang Z, Zang C, Wang YH. Genes Chromosomes Cancer. 2021 Aug 18. doi: 10.1002/gcc.22993. PMID: 34405474

Adnaviria: a New Realm for Archaeal Filamentous Viruses with Linear A-Form Double-Stranded DNA Genomes.  Krupovic M, Kuhn JH, Wang F, Baquero DP, Dolja VV, Egelman EH, Prangishvili D, Koonin EV. J Virol. 2021 Jul 12;95(15):e0067321. doi: 10.1128/JVI.00673-21. Epub 2021 Jul 12. PMID: 34011550

A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.  Enriquez-Hesles E, Smith DL Jr, Maqani N, Wierman MB, Sutcliffe MD, Fine RD, Kalita A, Santos SM, Muehlbauer MJ, Bain JR, Janes KA, Hartman JL 4th, Hirschey MD, Smith JS. J Biol Chem. 2021 Jan-Jun;296:100125. doi: 10.1074/jbc.RA120.015402. Epub 2020 Dec 2. PMID: 33243834

Comparative interactomes of HSF1 in stress and disease reveal a role for CTCF in HSF1-mediated gene regulation.  Burchfiel ET, Vihervaara A, Guertin MJ, Gomez-Pastor R, Thiele DJ. J Biol Chem. 2021 Jan-Jun;296:100097. doi: 10.1074/jbc.RA120.015452. Epub 2020 Nov 24. PMID: 33208463

ARF-AID: A Rapidly Inducible Protein Degradation System That Preserves Basal Endogenous Protein Levels.  Sathyan KM, Scott TG, Guertin MJ. Curr Protoc Mol Biol. 2020 Sep;132(1):e124. doi: 10.1002/cpmb.124. PMID: 32757370

C3(H2O) prevents rescue of complement-mediated C3 glomerulopathy in Cfh-/- Cfd-/- mice.  Zhang Y, Keenan A, Dai DF, May KS, Anderson EE, Lindorfer MA, Henrich JB, Pitcher GR, Taylor RP, Smith RJ. JCI Insight. 2020 May 7;5(9):e135758. doi: 10.1172/jci.insight.135758. PMID: 32376801

A Machine Learning Model Utilizing a Novel SNP Shows Enhanced Prediction of Coronary Artery Disease Severity.  Pattarabanjird T, Cress C, Nguyen A, Taylor A, Bekiranov S, McNamara C. Genes (Basel). 2020 Dec 1;11(12):1446. doi: 10.3390/genes11121446. PMID: 33271747

tRNA-derived fragments and microRNAs in the maternal-fetal interface of a mouse maternal-immune-activation autism model.  Su Z, Frost EL, Lammert CR, Przanowska RK, Lukens JR, Dutta A. RNA Biol. 2020 Aug;17(8):1183-1195. doi: 10.1080/15476286.2020.1721047. Epub 2020 Jan 31. PMID: 31983265

ADP-ribosyltransferases, an update on function and nomenclature.  Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawłowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M. FEBS J. 2021 Jul 29. doi: 10.1111/febs.16142. PMID: 34323016

PARP7 mono-ADP-ribosylates the Agonist Conformation of the Androgen Receptor in the Nucleus. Kamata T, Yang CS, Paschal BM. Biochem J. 2021 Jul 15:BCJ20210378. doi: 10.1042/BCJ20210378. Online ahead of print. PMID: 34264286

COCOA: coordinate covariation analysis of epigenetic heterogeneity.  Lawson JT, Smith JP, Bekiranov S, Garrett-Bakelman FE, Sheffield NC. Genome Biol. 2020 Sep 7;21(1):240. doi: 10.1186/s13059-020-02139-4. PMID: 32894181

Upregulation of human endogenous retrovirus-K (HML-2) mRNAs in hepatoblastoma: Identification of potential new immunotherapeutic targets and biomarkers.  Grabski DF, Ratan A, Gray LR, Bekiranov S, Rekosh D, Hammarskjold ML, Rasmussen SK. J Pediatr Surg. 2021 Feb;56(2):286-292. doi: 10.1016/j.jpedsurg.2020.05.022. Epub 2020 May 27. PMID: 32682541

A Condensed View of the Chromosome Passenger Complex.  Trivedi P, Stukenberg PT. Trends Cell Biol. 2020 Sep;30(9):676-687. doi: 10.1016/j.tcb.2020.06.005. Epub 2020 Jul 17. PMID: 32684321 Review.

The RNA helicase DHX36/G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat- associated translation.  Tseng YJ, Sandwith SN, Green KM, Chambers AE, Krans A, Raimer HM, Sharlow ME, Reisinger MA, Richardson AE, Routh ED, Smaldino MA, Wang YH, Vaughn JP, Todd PK, Smaldino PJ. J Biol Chem. 2021 Jun 23:100914. doi: 10.1016/j.jbc.2021.100914. PMID: 34174288

CDK6 is a therapeutic target in myelofibrosis.  Dutta A, Nath D, Yang Y, Le BT, Mohi G. Cancer Res. 2021 Jun 18:canres.0590.2021. doi: 10.1158/0008-5472.CAN-21-0590. PMID: 34145036

ATAC-Seq-based Identification of Extrachromosomal Circular DNA in Mammalian Cells and Its Validation Using Inverse PCR and FISH.  Su Z, Saha S, Paulsen T, Kumar P, Dutta A. Bio Protoc. 2021 May 5;11(9):e4003. doi: 10.21769/BioProtoc.4003. eCollection 2021 May 5. PMID: 34124304

Noncanonical Roles of tRNAs: tRNA Fragments and Beyond.  Su Z, Wilson B, Kumar P, Dutta A. Annu Rev Genet. 2020 Nov 23;54:47-69. doi: 10.1146/annurev-genet-022620-101840. Epub 2020 Aug 25. PMID: 32841070.

A Functional Variant on 9p21.3 Related to Glioma Risk Affects Enhancer Activity and Modulates Expression of CDKN2B-AS1.  Ali MW, Patro CPK, Devall M, Dampier CH, Plummer SJ, Kuscu C, Adli M, Lai RK, Casey G. Hum Mutat. 2021 Jun 21. doi: 10.1002/humu.24244. PMID: 34153138

Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome.  Zhang Y, Kremsdorf RA, Sperati CJ, Henriksen KJ, Mori M, Goodfellow RX, Pitcher GR, Benson CL, Borsa NG, Taylor RP, Nester CM, Smith RJH. Kidney Int. 2020 Nov;98(5):1265-1274. doi: 10.1016/j.kint.2020.05.028. Epub 2020 Jun 12. PMID: 32540405

PEPPRO: quality control and processing of nascent RNA profiling data.  Smith JP, Dutta AB, Sathyan KM, Guertin MJ, Sheffield NC. Genome Biol. 2021 May 15;22(1):155. doi: 10.1186/s13059-021-02349-4. PMID: 33992117

Adnaviria: a new realm for archaeal filamentous viruses with linear A-form double-stranded DNA genomes.  Krupovic M, Kuhn JH, Wang F, Baquero DP, Dolja VV, Egelman EH, Prangishvili D, Koonin EV. J Virol. 2021 May 19:JVI.00673-21. doi: 10.1128/JVI.00673-21. PMID: 34011550

Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome.  Matyszewski M, Zheng W, Lueck J, Mazanek Z, Mohideen N, Lau AY, Egelman EH, Sohn J. Nat Commun. 2021 May 12;12(1):2735. doi: 10.1038/s41467-021-23045-8. PMID: 33980849

Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament.  Zheng W, Peña A, Ilangovan A, Clark JN, Frankel G, Egelman EH, Costa TRD. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2022826118. doi: 10.1073/pnas.2022826118. PMID: 33397726

Structural Determination of a Filamentous Chaperone to Fabricate Electronically Conductive Metalloprotein Nanowires.  Chen YX, Ing NL, Wang F, Xu D, Sloan NB, Lam NT, Winter DL, Egelman EH, Hochbaum AI, Clark DS, Glover DJ. ACS Nano. 2020 Jun 23;14(6):6559-6569. doi: 10.1021/acsnano.9b09405. Epub 2020 May 7. PMID: 32347705

Single-cell sequencing of the small and AT-skewed genome of malaria parasites.  Liu S, Huckaby AC, Brown AC, Moore CC, Burbulis I, McConnell MJ, Güler JL. Genome Med. 2021 May 4;13(1):75. doi: 10.1186/s13073-021-00889-9. PMID: 33947449

Altering mammalian transcription networking with ADAADi: An inhibitor of ATP-dependent chromatin remodeling.  Rakesh R, Chanana UB, Hussain S, Sharma S, Goel K, Bisht D, Patne K, Swer PB, Hockensmith JW, Muthuswami R. PLoS One. 2021 May 17;16(5):e0251354. doi: 10.1371/journal.pone.0251354. eCollection 2021. PMID: 33999958

IGF1R and Src inhibition induce synergistic cytotoxicity in HNSCC through inhibition of FAK.  Lehman CE, Spencer A, Hall S, Shaw JJP, Wulfkuhle J, Petricoin EF, Bekiranov S, Jameson MJ, Gioeli D. Sci Rep. 2021 May 24;11(1):10826. doi: 10.1038/s41598-021-90289-1. PMID: 34031486

Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly.  Yang CS, Jividen K, Kamata T, Dworak N, Oostdyk L, Remlein B, Pourfarjam Y, Kim IK, Du KP, Abbas T, Sherman NE, Wotton D, Paschal BM. Nat Commun. 2021 May 11;12(1):2705. doi: 10.1038/s41467-021-23055-6. PMID: 33976187

High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability.  Matson DR, Denu RA, Zasadil LM, Burkard ME, Weaver BA, Flynn C, Stukenberg PT. BMC Cancer. 2021 Feb 23;21(1):186. doi: 10.1186/s12885-021-07893-7. PMID: 33622270

DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies.  Oostindie SC, van der Horst HJ, Kil LP, Strumane K, Overdijk MB, van den Brink EN, van den Brakel JHN, Rademaker HJ, van Kessel B, van den Noort J, Chamuleau MED, Mutis T, Lindorfer MA, Taylor RP, Schuurman J, Parren PWHI, Beurskens FJ, Breij ECW.Blood Cancer J. 2020 Apr 28;10(3):30. doi: 10.1038/s41408-020-0292-7. PMID: 32341336

A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.  Shibata E, Dutta A. J Biol Chem. 2020 Dec 11;295(50):16949-16959. doi: 10.1074/jbc.RA120.015450. Epub 2020 Sep 28.  PMID: 32989049

Risk-adapted, ofatumumab-based chemoimmunotherapy and consolidation in treatment-naïve chronic lymphocytic leukemia: a phase 2 study.  Desai S, Mo C, Gaglione EM, Yuan CM, Stetler-Stevenson M, Tian X, Maric I, Wake L, Farooqui MZ, Drinkwater DC, Soto S, Valdez J, Hughes TE, Nierman P, Lotter J, Marti GE, Pleyer C, Sun C, Superata J, Nichols C, Herman SEM, Lindorfer MA, Taylor RP, Wiestner A, Ahn IE. Leuk Lymphoma. 2021 Mar 2:1-17. doi: 10.1080/10428194.2021.1888379. PMID: 33653216

Cryo-EM is a powerful tool, but helical applications can have pitfalls.  Egelman EH , Wang F .Soft Matter. 2021 Mar 28;17(12):3291-3293. doi:  10.1039/d1sm00282a. Epub 2021 Mar 17. PMID: 33729271

Germline variants predictive of tumor mutational burden and immune checkpoint inhibitor efficacy. Chatrath A, Ratan A, Dutta A. iScience. 2021 Mar 4;24(3):102248. doi: 10.1016/j.isci.2021.102248. eCollection 2021 Mar 19. PMID: 33786423

What Is Extrachromosomal Circular DNA and What Does It Do?  Chiu RWK, Dutta A, Hensson AG, Lo YMD, Mischel P, Regenberg B. Clin Chem. 2020 Jun 1;66(6):754-759. doi: 10.1093/clinchem/hvaa096. PMID: 32470125

Gut microbiome communication with bone marrow regulates susceptibility to amebiasis.  Burgess SL, Leslie JL, Uddin J, Oakland DN, Gilchrist C, Moreau GB, Watanabe K, Saleh M, Simpson M, Thompson BA, Auble DT, Turner SD, Giallourou N, Swann J, Pu Z, Ma JZ, Haque R, Petri WA Jr. J Clin Invest. 2020 Aug 3;130(8):4019-4024. doi: 10.1172/JCI133605. PMID: 32369444

Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling. Kamata T, Yang CS, Melhuish TA, Frierson HF Jr, Wotton D, Paschal BM. Cells. 2021 Feb 9;10(2):363. doi: 10.3390/cells10020363. PMID: 33572475

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.  Srivastava S, Sahu U, Zhou Y, Hogan AK, Sathyan KM, Bodner J, Huang J, Wong KA, Khalatyan N, Savas JN, Ntziachristos P, Ben-Sahra I, Foltz DR. Sci Adv. 2021 Jan 27;7(5):eabc9781. doi: 10.1126/sciadv.abc9781. Print 2021 Jan. PMID: 33571115

Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia.  Rapaport F, Neelamraju Y, Baslan T, Hassane D, Gruszczynska A, Robert de Massy M, Farnoud N, Haddox S, Lee T, Medina-Martinez J, Sheridan C, Thurmond A, Becker M, Bekiranov S, Carroll M, Moses Murdock H, Valk PJM, Bullinger L, D’Andrea R, Lowe SW, Neuberg D, Levine RL, Melnick A, Garrett-Bakelman FE. Leukemia. 2021 Feb 12. doi: 10.1038/s41375-021-01153-0. PMID: 33580203

High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability.  Matson DR, Denu RA, Zasadil LM, Burkard ME, Weaver BA, Flynn C, Stukenberg PT. BMC Cancer. 2021 Feb 23;21(1):186. doi: 10.1186/s12885-021-07893-7. PMID: 33622270

Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer. Przanowski P, Lou S, Tihagam RD, Mondal T, Conlan C, Shivange G, Saltani I, Singh C, Xing K, Morris BB, Mayo MW, Teixeira L, Lehmann-Che J, Tushir-Singh J, Bhatnagar S. Cancer Res. 2020 Nov 1;80(21):4791-4804. doi: 10.1158/0008-5472.CAN-20-1459. Epub 2020 Aug 27. PMID: 32855208

The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma.  Caso R, Sanchez-Vega F, Tan KS, Mastrogiacomo B, Zhou J, Jones GD, Nguyen B, Schultz N, Connolly JG, Brandt WS, Bott MJ, Rocco G, Molena D, Isbell JM, Liu Y, Mayo MW, Adusumilli PS, Travis WD, Jones DR. J Thorac Oncol. 2020 Dec;15(12):1844-1856. doi: 10.1016/j.jtho.2020.08.005. Epub 2020 Aug 10. PMID: 32791233

Effects of working posture and roof slope on activation of lower limb muscles during shingle installation. Dutta A, Breloff SP, Dai F, Sinsel EW, Warren CM, Carey RE, Wu JZ. Ergonomics. 2020 Sep;63(9):1182-1193. doi: 10.

MYBL2-Driven Transcriptional Programs Link Replication Stress and Error-prone DNA Repair With Genomic Instability in Lung Adenocarcinoma.  Morris BB, Wages NA, Grant PA, Stukenberg PT, Gentzler RD, Hall RD, Akerley WL, Varghese TK, Arnold SM, Williams TM, Coppola V, Jones DR, Auble DT, Mayo MW. Front Oncol. 2021 Jan 8;10:585551. doi: 10.3389/fonc.2020.585551. eCollection 2020. PMID: 33489883

Quantum computing at the frontiers of biological sciences.  Emani PS, Warrell J, Anticevic A, Bekiranov S, Gandal M, McConnell MJ, Sapiro G, Aspuru-Guzik A, Baker JT, Bastiani M, Murray JD, Sotiropoulos SN, Taylor J, Senthil G, Lehner T, Gerstein MB, Harrow AW. Nat Methods. 2021 Jan 4. doi: 10.1038/s41592-020-01004-3. Online ahead of print. PMID: 33398186

A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism. Enriquez-Hesles E, Smith DL Jr, Maqani N, Wierman MB, Sutcliffe MD, Fine RD, Kalita A, Santos SM, Muehlbauer MJ, Bain JR, Janes KA, Hartman JL 4th, Hirschey MD, Smith JS. J Biol Chem. 2020 Dec 2;296:100125. doi: 10.1074/jbc.RA120.015402. Online ahead of print. PMID: 33460918

Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells.  Wei X, Yang J, Adair SJ, Ozturk H, Kuscu C, Lee KY, Kane WJ, O’Hara PE, Liu D, Demirlenk YM, Habieb AH, Yilmaz E, Dutta A, Bauer TW, Adli M. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28068-28079. doi: 10.1073/pnas.2009899117. Epub 2020 Oct 23.PMID: 33097661

Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A.  Lee KY, Dutta A. Cell Rep. 2021 Jan 26;34(4):108680. doi: 10.1016/j.celrep.2020.108680. PMID: 33503415

A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.  Shibata E, Dutta A. J Biol Chem. 2020 Dec 11;295(50):16949-16959. doi: 10.1074/jbc.RA120.015450. PMID: 33453950

U2af1 is required for survival and function of hematopoietic stem/progenitor cells.  Dutta A, Yang Y, Le BT, Zhang Y, Abdel-Wahab O, Zang C, Mohi G. Leukemia. 2021 Jan 7. doi: 10.1038/s41375-020-01116-x. Online ahead of print. PMID: 33414485

miR-206 family is important for mitochondrial and muscle function, but not essential for myogenesis in vitro.  Przanowska RK, Sobierajska E, Su Z, Jensen K, Przanowski P, Nagdas S, Kashatus JA, Kashatus DF, Bhatnagar S, Lukens JR, Dutta A. FASEB J. 2020 Jun;34(6):7687-7702. doi: 10.1096/fj.201902855RR. Epub 2020 Apr 11. PMID: 32277852

The pan-cancer landscape of prognostic germline variants in 10,582 patients.  Chatrath A, Przanowska R, Kiran S, Su Z, Saha S, Wilson B, Tsunematsu T, Ahn JH, Lee KY, Paulsen T, Sobierajska E, Kiran M, Tang X, Li T, Kumar P, Ratan A, Dutta A. Genome Med. 2020 Feb 17;12(1):15. doi: 10.1186/s13073-020-0718-7. PMID: 32066500

Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials.  Wang F, Gnewou O, Modlin C, Beltran LC, Xu C, Su Z, Juneja P, Grigoryan G, Egelman EH, Conticello VP. Nat Commun. 2021 Jan 18;12(1):407. doi: 10.1038/s41467-020-20689-w. PMID: 33462223

Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament.  Zheng W, Peña A, Ilangovan A, Clark JN, Frankel G, Egelman EH, Costa TRD. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2022826118. doi: 10.1073/pnas.2022826118. PMID: 33397726