Departmental Publications 2021

DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies.  Oostindie SC, van der Horst HJ, Kil LP, Strumane K, Overdijk MB, van den Brink EN, van den Brakel JHN, Rademaker HJ, van Kessel B, van den Noort J, Chamuleau MED, Mutis T, Lindorfer MA, Taylor RP, Schuurman J, Parren PWHI, Beurskens FJ, Breij ECW.Blood Cancer J. 2020 Apr 28;10(3):30. doi: 10.1038/s41408-020-0292-7. PMID: 32341336

A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.  Shibata E, Dutta A. J Biol Chem. 2020 Dec 11;295(50):16949-16959. doi: 10.1074/jbc.RA120.015450. Epub 2020 Sep 28.  PMID: 32989049

Risk-adapted, ofatumumab-based chemoimmunotherapy and consolidation in treatment-naïve chronic lymphocytic leukemia: a phase 2 study.  Desai S, Mo C, Gaglione EM, Yuan CM, Stetler-Stevenson M, Tian X, Maric I, Wake L, Farooqui MZ, Drinkwater DC, Soto S, Valdez J, Hughes TE, Nierman P, Lotter J, Marti GE, Pleyer C, Sun C, Superata J, Nichols C, Herman SEM, Lindorfer MA, Taylor RP, Wiestner A, Ahn IE. Leuk Lymphoma. 2021 Mar 2:1-17. doi: 10.1080/10428194.2021.1888379. PMID: 33653216

Cryo-EM is a powerful tool, but helical applications can have pitfalls.  Egelman EH , Wang F .Soft Matter. 2021 Mar 28;17(12):3291-3293. doi:  10.1039/d1sm00282a. Epub 2021 Mar 17. PMID: 33729271

Germline variants predictive of tumor mutational burden and immune checkpoint inhibitor efficacy. Chatrath A, Ratan A, Dutta A. iScience. 2021 Mar 4;24(3):102248. doi: 10.1016/j.isci.2021.102248. eCollection 2021 Mar 19. PMID: 33786423

What Is Extrachromosomal Circular DNA and What Does It Do?  Chiu RWK, Dutta A, Hensson AG, Lo YMD, Mischel P, Regenberg B. Clin Chem. 2020 Jun 1;66(6):754-759. doi: 10.1093/clinchem/hvaa096. PMID: 32470125

Gut microbiome communication with bone marrow regulates susceptibility to amebiasis.  Burgess SL, Leslie JL, Uddin J, Oakland DN, Gilchrist C, Moreau GB, Watanabe K, Saleh M, Simpson M, Thompson BA, Auble DT, Turner SD, Giallourou N, Swann J, Pu Z, Ma JZ, Haque R, Petri WA Jr. J Clin Invest. 2020 Aug 3;130(8):4019-4024. doi: 10.1172/JCI133605. PMID: 32369444

Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling. Kamata T, Yang CS, Melhuish TA, Frierson HF Jr, Wotton D, Paschal BM. Cells. 2021 Feb 9;10(2):363. doi: 10.3390/cells10020363. PMID: 33572475

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.  Srivastava S, Sahu U, Zhou Y, Hogan AK, Sathyan KM, Bodner J, Huang J, Wong KA, Khalatyan N, Savas JN, Ntziachristos P, Ben-Sahra I, Foltz DR. Sci Adv. 2021 Jan 27;7(5):eabc9781. doi: 10.1126/sciadv.abc9781. Print 2021 Jan. PMID: 33571115

Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia.  Rapaport F, Neelamraju Y, Baslan T, Hassane D, Gruszczynska A, Robert de Massy M, Farnoud N, Haddox S, Lee T, Medina-Martinez J, Sheridan C, Thurmond A, Becker M, Bekiranov S, Carroll M, Moses Murdock H, Valk PJM, Bullinger L, D’Andrea R, Lowe SW, Neuberg D, Levine RL, Melnick A, Garrett-Bakelman FE. Leukemia. 2021 Feb 12. doi: 10.1038/s41375-021-01153-0. PMID: 33580203

High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability.  Matson DR, Denu RA, Zasadil LM, Burkard ME, Weaver BA, Flynn C, Stukenberg PT. BMC Cancer. 2021 Feb 23;21(1):186. doi: 10.1186/s12885-021-07893-7. PMID: 33622270

Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer. Przanowski P, Lou S, Tihagam RD, Mondal T, Conlan C, Shivange G, Saltani I, Singh C, Xing K, Morris BB, Mayo MW, Teixeira L, Lehmann-Che J, Tushir-Singh J, Bhatnagar S. Cancer Res. 2020 Nov 1;80(21):4791-4804. doi: 10.1158/0008-5472.CAN-20-1459. Epub 2020 Aug 27. PMID: 32855208

The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma.  Caso R, Sanchez-Vega F, Tan KS, Mastrogiacomo B, Zhou J, Jones GD, Nguyen B, Schultz N, Connolly JG, Brandt WS, Bott MJ, Rocco G, Molena D, Isbell JM, Liu Y, Mayo MW, Adusumilli PS, Travis WD, Jones DR. J Thorac Oncol. 2020 Dec;15(12):1844-1856. doi: 10.1016/j.jtho.2020.08.005. Epub 2020 Aug 10. PMID: 32791233

Effects of working posture and roof slope on activation of lower limb muscles during shingle installation. Dutta A, Breloff SP, Dai F, Sinsel EW, Warren CM, Carey RE, Wu JZ. Ergonomics. 2020 Sep;63(9):1182-1193. doi: 10.

MYBL2-Driven Transcriptional Programs Link Replication Stress and Error-prone DNA Repair With Genomic Instability in Lung Adenocarcinoma.  Morris BB, Wages NA, Grant PA, Stukenberg PT, Gentzler RD, Hall RD, Akerley WL, Varghese TK, Arnold SM, Williams TM, Coppola V, Jones DR, Auble DT, Mayo MW. Front Oncol. 2021 Jan 8;10:585551. doi: 10.3389/fonc.2020.585551. eCollection 2020. PMID: 33489883

Quantum computing at the frontiers of biological sciences.  Emani PS, Warrell J, Anticevic A, Bekiranov S, Gandal M, McConnell MJ, Sapiro G, Aspuru-Guzik A, Baker JT, Bastiani M, Murray JD, Sotiropoulos SN, Taylor J, Senthil G, Lehner T, Gerstein MB, Harrow AW. Nat Methods. 2021 Jan 4. doi: 10.1038/s41592-020-01004-3. Online ahead of print. PMID: 33398186

A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism. Enriquez-Hesles E, Smith DL Jr, Maqani N, Wierman MB, Sutcliffe MD, Fine RD, Kalita A, Santos SM, Muehlbauer MJ, Bain JR, Janes KA, Hartman JL 4th, Hirschey MD, Smith JS. J Biol Chem. 2020 Dec 2;296:100125. doi: 10.1074/jbc.RA120.015402. Online ahead of print. PMID: 33460918

Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells.  Wei X, Yang J, Adair SJ, Ozturk H, Kuscu C, Lee KY, Kane WJ, O’Hara PE, Liu D, Demirlenk YM, Habieb AH, Yilmaz E, Dutta A, Bauer TW, Adli M. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28068-28079. doi: 10.1073/pnas.2009899117. Epub 2020 Oct 23.PMID: 33097661

Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A.  Lee KY, Dutta A. Cell Rep. 2021 Jan 26;34(4):108680. doi: 10.1016/j.celrep.2020.108680. PMID: 33503415

A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.  Shibata E, Dutta A. J Biol Chem. 2020 Dec 11;295(50):16949-16959. doi: 10.1074/jbc.RA120.015450. PMID: 33453950

U2af1 is required for survival and function of hematopoietic stem/progenitor cells.  Dutta A, Yang Y, Le BT, Zhang Y, Abdel-Wahab O, Zang C, Mohi G. Leukemia. 2021 Jan 7. doi: 10.1038/s41375-020-01116-x. Online ahead of print. PMID: 33414485

miR-206 family is important for mitochondrial and muscle function, but not essential for myogenesis in vitro.  Przanowska RK, Sobierajska E, Su Z, Jensen K, Przanowski P, Nagdas S, Kashatus JA, Kashatus DF, Bhatnagar S, Lukens JR, Dutta A. FASEB J. 2020 Jun;34(6):7687-7702. doi: 10.1096/fj.201902855RR. Epub 2020 Apr 11. PMID: 32277852

The pan-cancer landscape of prognostic germline variants in 10,582 patients.  Chatrath A, Przanowska R, Kiran S, Su Z, Saha S, Wilson B, Tsunematsu T, Ahn JH, Lee KY, Paulsen T, Sobierajska E, Kiran M, Tang X, Li T, Kumar P, Ratan A, Dutta A. Genome Med. 2020 Feb 17;12(1):15. doi: 10.1186/s13073-020-0718-7. PMID: 32066500

Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials.  Wang F, Gnewou O, Modlin C, Beltran LC, Xu C, Su Z, Juneja P, Grigoryan G, Egelman EH, Conticello VP. Nat Commun. 2021 Jan 18;12(1):407. doi: 10.1038/s41467-020-20689-w. PMID: 33462223

Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament.  Zheng W, Peña A, Ilangovan A, Clark JN, Frankel G, Egelman EH, Costa TRD. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2022826118. doi: 10.1073/pnas.2022826118. PMID: 33397726