Departmental Publications 2019

Methods in Nuclear Architecture and Transport. Paschal BM. Methods. 2019 Mar 15;157:1-2. doi: 10.1016/j.ymeth.2019.02.020. No abstract available. PMID: 30832896

Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging of <i>Saccharomyces cerevisiae</i>. Fine RD, Maqani N, Li M, Franck E, Smith JS. Genetics. 2019 Mar 6. pii: genetics.302047.2019. doi: 10.1534/genetics.119.302047. PMID: 30842210

P190RhoGAP prevents mitotic spindle fragmentation and is required to activate Aurora A kinase at acentriolar poles. Manukyan A, Sargsyan L, Parsons SJ, Stukenberg PT. Chromosoma. 2018 Sep;127(3):375-386. doi: 10.1007/s00412-018-0670-0. Epub 2018 Apr 14. PMID: 29656322

Null donors favor prepared immunologists. Taylor RP. Blood. 2019 Mar 28;133(13):1389-1390. doi: 10.1182/blood-2019-01-898775. No abstract available. PMID: 30923104

Histone H3 lysine 4 methylation signature associated with human undernutrition. Uchiyama R, Kupkova K, Shetty SJ, Linford AS, Pray-Grant MG, Wagar LE, Davis MM, Haque R, Gaultier A, Mayo MW, Grant PA, Petri WA Jr, Bekiranov S, Auble DT. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11264-E11273. doi: 10.1073/pnas.1722125115. Epub 2018 Nov 12. PMID: 30420518

NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer. Szymura SJ, Zaemes JP, Allison DF, Clift SH, D’Innocenzi JM, Gray LG, McKenna BD, Morris BB, Bekiranov S, LeGallo RD, Jones DR, Mayo MW. Cell Commun Signal. 2019 Mar 18;17(1):24. doi: 10.1186/s12964-019-0335-5. PMID: 30885209

Histone H3 lysine 4 methylation signature associated with human undernutrition. Uchiyama R, Kupkova K, Shetty SJ, Linford AS, Pray-Grant MG, Wagar LE, Davis MM, Haque R, Gaultier A, Mayo MW, Grant PA, Petri WA Jr, Bekiranov S, Auble DT. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11264-E11273. doi: 10.1073/pnas.1722125115. Epub 2018 Nov 12. PMID: 30420518

Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promotersPaulsen T, Shibata Y, Kumar P, Dillon L, Dutta A. Nucleic Acids Res. 2019 Mar 4. pii: gkz155. doi: 10.1093/nar/gkz155. [Epub ahead of print] PMID: 30828735

Improved molecular karyotyping in glioblastoma. Burbulis IE, Wierman MB, Wolpert M, Haakenson M, Lopes MB, Schiff D, Hicks J, Loe J, Ratan A, McConnell MJ. Mutat Res. 2018 Sep;811:16-26. doi: 10.1016/j.mrfmmm.2018.06.002. Epub 2018 Jul 8. PMID: 30055482

Dissecting the Genetics of Osteoporosis using Systems Approaches. Al-Barghouthi BM, Farber CR. Trends Genet. 2019 Jan;35(1):55-67. doi: 10.1016/j.tig.2018.10.004. Epub 2018 Nov 20. PMID: 30470485

TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth. Shah A, Melhuish TA, Fox TE, Frierson HF Jr, Wotton D. Genes Dev. 2019 Feb 26. doi: 10.1101/gad.320127.118. PMID: 30808659

Analysis of transcriptional activity by the Myt1 and Myt1l transcription factors. Manukyan A, Kowalczyk I, Melhuish TA, Lemiesz A, Wotton D. J Cell Biochem. 2018 Jun;119(6):4644-4655. doi: 10.1002/jcb.26636. Epub 2018 Mar 9. PMID: 29291346

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering. Oostindie SC, van der Horst HJ, Lindorfer MA, Cook EM, Tupitza JC, Zent CS, Burack R, VanDerMeid KR, Strumane K, Chamuleau MED, Mutis T, de Jong RN, Schuurman J, Breij ECW, Beurskens FJ, Parren PWHI, Taylor RP. Haematologica. 2019 Feb 21. pii: haematol.2018.207266. doi: 10.3324/haematol.2018.207266. PMID: 30792198

Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer. Yang J, Wei X, Tufan T, Kuscu C, Unlu H, Farooq S, Demirtas E, Paschal BM, Adli M. Genome Biol. 2018 Nov 7;19(1):190. doi: 10.1186/s13059-018-1572-4. PMID: 30404658

The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway. Trivedi P, Zaytsev AV, Godzi M, Ataullakhanov FI, Grishchuk EL, Stukenberg PT. Nat Commun. 2019 Feb 8;10(1):682. doi: 10.1038/s41467-019-08418-4. PMID: 30737408

STAT3 mutations are not sufficient to induce large granular lymphocytic leukaemia in mice. Dutta A, Yan D, Hutchison RE, Mohi G. Br J Haematol. 2018 Mar;180(6):911-915. doi: 10.1111/bjh.14487. Epub 2016 Dec 26. No abstract available. PMID: 28025836

Conformational changes and catalytic inefficiency associated with Mot1-mediated TBP-DNA dissociation. Heiss G, Ploetz E, Voith von Voithenberg L, Viswanathan R, Glaser S, Schluesche P, Madhira S, Meisterernst M, Auble DT, Lamb DC. Nucleic Acids Res. 2019 Jan 15. doi: 10.1093/nar/gky1322. PMID: 30649478

BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer. Muthuswami R, Bailey L, Rakesh R, Imbalzano AN, Nickerson JA, Hockensmith JW J Cell Physiol. 2019 Jan 22. doi: 10.1002/jcp.28161. PMID: 30667054

Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex. Chronister WD, Burbulis IE, Wierman MB, Wolpert MJ, Haakenson MF, Smith ACB, Kleinman JE, Hyde TM, Weinberger DR, Bekiranov S, McConnell MJ. Cell Rep. 2019 Jan 22;26(4):825-835.e7. doi: 10.1016/j.celrep.2018.12.107. PMID: 30673605

Molecular mechanism for NLRP6 inflammasome assembly and activation. Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Proc Natl Acad Sci U S A. 2019 Jan 23. pii: 201817221. doi: 10.1073/pnas.1817221116. PMID: 30674671

The Germline Variants rs61757955 and rs34988193 are Predictive of Survival in Lower Grade Glioma Patients. Chatrath A, Kiran M, Kumar P, Ratan A, Dutta A. Mol Cancer Res. 2019 Jan 16. pii: molcanres.0996.2018. doi: 10.1158/1541-7786.MCR-18-0996. PMID: 30651372