Michael McConnell

McConnell, Michael J

Primary Appointment

Assistant Professor, Biochemistry and Molecular Genetics

Education

  • Postdoc, Stanford University
  • Postdoc, Harvard Medical School
  • BS, Zoology, North Carolina State University
  • PhD, Biomedical Sciences, University of California, San Diego

Contact Information

PO Box 800733
1340 JPA Pinn Hall Room 6042
Charlottesville, VA 22908
Telephone: (434) 924-0154
Fax: (434) 924-5069
Email: mjm2zv@virginia.edu
Website: http://www.mcconnell-lab.org

Research Disciplines

Biochemistry, Bioinformatics and Genomics, Biotechnology, Computational Biology, Epigenetics, Genetics, Molecular Biology, Neuroimmunology, Neuroscience, Translational Science

Research Interests

The Cause and Consequence of Somatic Mosaicism in Neurons

Research Description

The brain is a genetic mosaic. Neuron-to-neuron genomic differences - brought about by endogenous mobile element activity, by idiosyncratic sub-chromosomal amplifications and deletions, and by whole chromosome gains and losses – are hypothesized to “individualize” behavioral phenotypes. To explore the causes and consequences of genetic mosaicism in neural circuits, my laboratory develops high-throughput single cell approaches and employs these approaches to study human induced pluripotent stem cell (hiPSC)-derived neurons, as well as transgenic mice. We have three immediate research goals: 1) determine if genetic mosaicism leads to somatic selection during the development of neural circuits; 2) understand how genetic mosaicism affects the performance of neural circuits; and 3) discover genes that mediate the propensity for genetic mosaicism. Moreover, altered levels of mosaicism have been associated with neurodegenerative (e.g., Ataxia-telangiectasia) and neuropsychiatric disorders (e.g., schizophrenia and Rett’s syndrome). A deeper understanding of these and other neurological disorders is expected from ever-increasing understanding and measurement of neuronal genomic diversity.

Selected Publications