Michael McConnell UVa Faculty Collaborative Research Interests
The brain is a genetic mosaic with neuron-to-neuron genomic differences. Altered levels of mosaicism have been associated with neurodegenerative (e.g., Ataxia-telangiectasia) and neuropsychiatric disorders (e.g., schizophrenia and Rett’s syndrome). A deeper understanding of these and other neurological disorders is expected from ever-increasing understanding and measurement of neuronal genomic diversity.
The Cause and Consequence of Somatic Mosaicism in Neurons
Brain tumor clinical trials, brain tumor epidemiology
Howard Goodkin, Shure Professor of Pediatric Neurology
Erin Foff, Assistant Professor of Neurology