Bryce Paschal UVa Faculty Collaborative Research Interests

The overall goal of my laboratory is to understand how signal transduction pathways are altered in human disease. We study prostate cancer, with a focus on androgen signaling from the cytoplasm to the nucleus and how this pathway is altered during prostate cancer progression to the therapy-resistant state. We also study the premature aging syndrome Progeria, with a focus on how changes in nuclear architecture change signal transduction pathways that promote aging at the cellular level.

Bryce Paschal

Paschal, Bryce M.

Nuclear Transport, Signaling, and Cancer

David Wotton

Wotton, David

Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

Mazhar Adli

Adli, Mazhar

Identify and target key genomic and epigenomic drivers in cancer

Michael McConnell

McConnell, Michael J

The Cause and Consequence of Somatic Mosaicism in Neurons

Henry Frierson

Frierson, Henry F.

Role of genes and gene products in prostate, breast, and salivary gland cancers

Aakrosh Ratan

Ratan, Aakrosh

Genomics, Molecular Evolution, Algorithm Design and Analysis


Dan Theodorescu, Director of  Cancer Center, U. Colorado, Denver

Ralph Kehlenbach, Group leader at the Department of Molecular Biology in Göttingen