The overall goal of my laboratory is to understand how signal transduction pathways are altered in human disease. We study prostate cancer, with a focus on androgen signaling from the cytoplasm to the nucleus and how this pathway is altered during prostate cancer progression to the therapy-resistant state. We also study the premature aging syndrome Progeria, with a focus on how changes in nuclear architecture change signal transduction pathways that promote aging at the cellular level.
Nuclear Transport, Signaling, and Cancer
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Role of genes and gene products in prostate, breast, and salivary gland cancers
Genomics, Molecular Evolution, Algorithm Design and Analysis