Abbas, Tarek A.

Tarek Abbas

Tarek A. Abbas

Primary Appointment

Radiation Oncology

Education

  • BA, Biology, Hunter College, City University of New York, NY
  • MA, Cancer Biology, Hunter College, City University of New York, NY
  • MPH, Cancer Biology, The Graduate Center, (CUNY), NY
  • PhD, City University of New York, Hunter College

Contact Information

1300 Jefferson Park Avenue, Rm 7141 West Complex
PO Box 800383
Charlottesville, VA 22903
Telephone: 434-243-9222
Fax: 434-243-9261
Email: abbas@virginia.edu
Website: http://bims.virginia.edu/faculty/tarek-a-abbas/

Research Interests

The Ubiquitin System and Human Cancer

Research Description

The Ubiquitin System Research in my laboratory is focused on understanding the role of the ubiquitin system in the development and progression of human cancer and its role in promoting cellular responses to current therapeutic agents, such as ionizing radiation, and the development of resistance to anti-cancer agents. We are particularly interested in investigating the regulated process of protein ubiquitination and proteolysis of DNA sensing and repair molecules. Currently, there are a handful of examples where DNA repair proteins are regulated at the level of ubiquitin-dependent proteolysis and current evidence suggest that many others are yet to be identified specifically in post-repair recovery.

Thus, we hope this line of investigation will lead to the genetic and biochemical characterization of novel pathways that can be potentially exploited for therapeutic intervention.

A second focus of our research is to understand how the activity of the various components of the ubiquitin system is regulated and how deregulation of such activity impact or modulate downstream cellular responses. Our long-term goal is to identify some of the basic principles that govern cellular homeostasis and safeguard against cancer development, and ultimately applying knowledge and technology in preventing or treating cancer when these safeguarding mechanisms fail to function.

Selected Publications