Departmental Publications 2017

The Modifier of Transcription 1 (Mot1) ATPase and Spt16 Histone Chaperone Co-regulate Transcription through Preinitiation Complex Assembly and Nucleosome Organization.
True JD, Muldoon JJ, Carver MN, Poorey K, Shetty SJ, Bekiranov S, Auble DT. J Biol Chem. 2016 Jul 15;291(29):15307-19. doi: 10.1074/jbc.M116.735134. Epub 2016 May 16. PMID: 27226635
Neutrophils: positive or negative? Taylor RP. Blood. 2017 May 11;129(19):2596-2597. doi: 10.1182/blood-2017-03-774695. PMID: 28495923
Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.Yang CS, Jividen K, Spencer A, Dworak N, Ni L, Oostdyk LT, Chatterjee M, Kuśmider B, Reon B, Parlak M, Gorbunova V, Abbas T, Jeffery E, Sherman NE, Paschal BM. Mol Cell. 2017 May 18;66(4):503-516.e5. doi: 10.1016/j.molcel.2017.04.028. PMID: 28525742
Normal and Cancerous Tissues Release extrachromosomal circular DNA (eccDNA) into the Circulation. Kumar P, Dillon L, Shibata Y, Jazaeri AA, Jones DR, Dutta A. Mol Cancer Res. 2017 May 26. pii: molcanres.0095.2016. doi: 10.1158/1541-7786.MCR-17-0095. PMID: 28550083
Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis. Reon BJ, Anaya J, Zhang Y, Mandell J, Purow B, Abounader R, Dutta A. PLoS Med. 2016 Dec 6;13(12):e1002192. doi: 10.1371/journal.pmed.1002192. eCollection 2016 Dec. PMID: 27923049
Molecular Mechanism of Mot1, a TATA-binding Protein (TBP)-DNA Dissociating Enzyme. Viswanathan R, True JD, Auble DT. J Biol Chem. 2016 Jul 22;291(30):15714-26. doi: 10.1074/jbc.M116.730366. Epub 2016 Jun 2. PMID: 27255709
Mechanism of Ska Recruitment by Ndc80 Complexes to Kinetochores. Janczyk PŁ, Skorupka KA, Tooley JG, Matson DR, Kestner CA, West T, Pornillos O, Stukenberg PT. Dev Cell. 2017 May 22;41(4):438-449.e4. doi: 10.1016/j.devcel.2017.04.020. PMID: 28535377
Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation. Duarte FM, Fuda NJ, Mahat DB, Core LJ, Guertin MJ, Lis JT. Genes Dev. 2016 Aug 1;30(15):1731-46. doi: 10.1101/gad.284430.116. Epub 2016 Aug 4. PMID: 27492368
Caloric restriction extends yeast chronological lifespan by optimizing the Snf1 (AMPK) signaling pathway. Wierman MB, Maqani N, Strickler E, Li M, Smith JS. Mol Cell Biol. 2017 Apr 3. pii: MCB.00562-16. doi: 10.1128/MCB.00562-16. PMID: 28373292
Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9. Qin P, Parlak M, Kuscu C, Bandaria J, Mir M, Szlachta K, Singh R, Darzacq X, Yildiz A, Adli M. Nat Commun. 2017 Mar 14;8:14725. doi: 10.1038/ncomms14725. PMID: 28290446
α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere. Sathyan KM, Fachinetti D, Foltz DR. Nat Commun. 2017 Mar 7;8:14678. doi: 10.1038/ncomms14678. PMID: 28266506
SUMO and Chromatin Remodeling. Wotton D, Pemberton LF, Merrill-Schools J. Adv Exp Med Biol. 2017;963:35-50. doi: 10.1007/978-3-319-50044-7_3. PMID: 28197905
Genome-wide identification of basic helix-loop helix and NF-1 motifs underlying GR binding sites in male rat hippocampus. Pooley JR, Flynn BP, Grøntved L, Baek S, Guertin MJ, Kershaw YM, Birnie MT, Pellatt A, Rivers CA, Schiltz RL, Hager GL, Lightman SL, Conway-Campbell BL. Endocrinology. 2017 Feb 13. doi: 10.1210/en.2016-1929. No abstract available. PMID: 28200020
Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. Illendula A, Gilmour J, Grembecka J, Tirumala VS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH. EBioMedicine. 2016 Jun;8:117-31. doi: 10.1016/j.ebiom.2016.04.032. PMID: 27428424
The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores. Sivakumar S, Janczyk PŁ, Qu Q, Brautigam CA, Stukenberg PT, Yu H, Gorbsky GJ. Elife. 2016 Mar 16;5. pii: e12902. doi: 10.7554/eLife.12902. PMID: 26981768
DNA Fragile Site Breakage as a Measure of Chemical Exposure and Predictor of Individual Susceptibility to Form Oncogenic Rearrangements. Lehman CE, Dillon LW, Nikiforov YE, Wang YH. Carcinogenesis. 2017 Jan 9. pii: bgw210. doi: 10.1093/carcin/bgw210.  PMID: 28069693
RNA synthesis is associated with multiple TBP-chromatin binding events. Zaidi HA, Auble DT, Bekiranov S. Sci Rep. 2017 Jan 4;7:39631. doi: 10.1038/srep39631. PMID: 28051102
Pericyte and immune cells contribute to complement activation in tubulointerstitial fibrosis.Xavier S, Sahu RK, Landes SG, Yu J, Taylor RP, Ayyadevara S, Megyesi J, Stallcup WB, Duffield JS, Reis ES, Lambris JD, Portilla D. Am J Physiol Renal Physiol. 2017 Jan 4:ajprenal.00604.2016. doi: 10.1152/ajprenal.00604.2016. PMID: 28052876
Single neuron transcriptome analysis can reveal more than cell type classification: Does it matter if every neuron is unique? Harbom LJ, Chronister WD, McConnell MJ. Bioessays. 2016 Feb;38(2):157-61. doi: 10.1002/bies.201500097. Review. PMID: 26749010