Gene expression can be regulated epigenetically by environmental variables that impact the levels of modifications to chromatin proteins and DNA. We are studying the relationship between such epigenetic signatures and disease states including malnutrition and type I diabetes.
Molecular Mechanisms of Transcriptional Regulation
Genetics of Type 1 Diabetes
Molecular mechanisms of pathogenesis of parasitic infection
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis