Bryce Paschal UVa Faculty Collaborative Research Interests

The overall goal of my laboratory is to understand how signal transduction pathways are altered in human disease. We study prostate cancer, with a focus on androgen signaling from the cytoplasm to the nucleus and how this pathway is altered during prostate cancer progression to the therapy-resistant state. We also study the premature aging syndrome Progeria, with a focus on how changes in nuclear architecture change signal transduction pathways that promote aging at the cellular level.

Bryce Paschal

Paschal, Bryce M.

Nuclear Transport, Signaling, and Cancer

 
David Wotton

Wotton, David

Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

 
Mazhar Adli

Adli, Mazhar

Understanding and manipulating the genetics and epigenetics information to study stem cells, differentiation and cancer

 
Michael McConnell

McConnell, Michael J

The Cause and Consequence of Somatic Mosaicism in Neurons

 
Henry Frierson

Frierson, Henry F.

Role of genes and gene products in prostate, breast, and salivary gland cancers

 
Aakrosh Ratan

Ratan, Aakrosh

Genomics, Molecular Evolution, Algorithm Design and Analysis

EXTRAMURAL COLLABORATORS:

Dan Theodorescu, Director of  Cancer Center, U. Colorado, Denver

http://www.ucdenver.edu/academics/colleges/medicalschool/departments/Pathology/academicprograms/cancerbiology/Pages/theodorescu_canbio.aspx

Ralph Kehlenbach, Group leader at the Department of Molecular Biology in Göttingen

http://www.biochemie.uni-goettingen.de/index.php?id=306