UVA Study Reveals How Mutation Boosts Cancer Risk

November 10, 2021 by hn6u@virginia.edu

illustration of gene mutations Researchers at the University of Virginia School of Medicine have discovered how a common gene mutation robs people of natural cancer protection.

Hao Jiang, of the UVA Cancer Center, and his collaborators have revealed why a mutation in the UTX gene disrupts cells’ ability to suppress tumors. The gene product, they found, forms tiny droplets in cells that help prevent tumor formation. But the mutation throws a wrench in that important process, leaving affected people vulnerable.

The new understanding of this vulnerability will help scientists and doctors as they seek better ways to battle and prevent cancer.”

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