Mohi Lab

The major goal of our research is to improve understanding of the genetic and molecular basis for development and progression of blood cancers such as, myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Our lab utilizes tissue culture cell lines, primary cells from patients and genetically engineered mouse models to characterize the effects of gene mutations in MPN and MDS and investigate their effects on cell signaling and gene expression changes. We are also studying the effects of mutations in epigenetic modifiers and RNA splicing factors in the development and progression of MDS and MPN. In addition, we are investigating the mechanisms involved in tumor progression, metastasis and drug-resistance in breast cancer. The ultimate goal of our research is to identify new therapeutic targets for blood and breast cancers, and develop novel targeted therapies that are more potent and less toxic for cancer patients. Our research efforts include both basic and translational studies. We are interested in translating our research findings to the clinic.