Congratulations to Robyn Sherman and Zeming (Eileen) Zheng in the Bhatnagar Lab. They have been selected as 2017/2018 Double Hoo Award recipients for their project entitled “Awakening the Silent X-chromosome for Rett Syndrome Therapeutics”. Their project is entitled: Rett Syndrome (RTT) is a childhood neurodevelopmental disorder that primarily affects females, due to functional heterozygosity of the X-linked gene MECP2. RTT girls are mosaic for the MECP2 mutation due to random X-Chromosome Inactivation. We are using disease specific neurons derived from induced-pluripotent stem cell (iPSC) to pharmacologically reactivate the silent wild-type MECP2 on the X-chromosome for RTT therapeutics.
This award is administered by the Center for Undergraduate Excellence. Undergraduate Research, Center for Undergraduate Excellence, U.Va. The Double Hoo Research Grant supports pairs of undergraduate and graduate scholars seeking to pursue joint research projects. The award is intended to encourage collaborative interaction between the undergraduate and graduate communities at the University. Proposals from all schools at the University are considered.